Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis

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Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant : a 14-cohort meta-analysis

Kanoni, Stavroula (author)

Nettleton, Jennifer A (author)

Hivert, Marie-France (author)

Ye, Zheng (author)

van Rooij, Frank JA (author)

Shungin, Dmitry (author): Lund University,Lunds universitet,Umeå universitet,Medicin,Institutionen för odontologi,Department of Clinical Sciences, Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups

Sonestedt, Emily (author): Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups

Ngwa, Julius S (author)

Wojczynski, Mary K (author)

Lemaitre, Rozenn N (author)

Gustafsson, Stefan (author)

Anderson, Jennifer S (author)

Tanaka, Toshiko (author)

Hindy, George (author): Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups

Saylor, Georgia (author)

Renström, Frida (author): Umeå universitet,Medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Bennett, Amanda J (author)

van Duijn, Cornelia M (author)

Florez, Jose C (author)

Fox, Caroline S (author)

Hofman, Albert (author)

Hoogeveen, Ron C (author)

Houston, Denise K (author)

Hu, Frank B (author)

Franks, Paul (author): Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups

Johansson, Ingegerd (author): Umeå universitet,Institutionen för odontologi

Lind, Lars (author): Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin

Liu, Yongmei (author)

McKeown, Nicola (author)

Ordovas, Jose (author)

Pankow, James S (author)

Sijbrands, Eric JG (author)

Syvänen, Ann-Christine (author): Uppsala universitet,Molekylär medicin

Uitterlinden, André G (author)

Yannakoulia, Mary (author)

Zillikens, M Carola (author)

Wareham, Nick J (author)

Prokopenko, Inga (author)

Bandinelli, Stefania (author)

Forouhi, Nita G (author)

Cupples, L Adrienne (author)

Loos, Ruth J (author)

Hallmans, Göran (author): Umeå universitet,Näringsforskning,Medicin

Dupuis, Josée (author)

Langenberg, Claudia (author)

Ferrucci, Luigi (author)

Kritchevsky, Stephen B (author)

McCarthy, Mark I (author)

Ingelsson, Erik (author): Karolinska Institutet

Borecki, Ingrid B (author)

Witteman, Jacqueline CM (author)

Orho-Melander, Marju (author): Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups

Siscovick, David S (author)

Meigs, James B (author)

Franks, Paul W (author): Umeå universitet,Medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Dedoussis, George V (author)

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(creator_code:org_t)

2011-08-20
2011
English.
In: Diabetes. - Alexandria : American diabetes association. - 0012-1797 .- 1939-327X. ; 60:9, s. 2407-2416

Related links:: https://diabetes.dia...; show more...; http://dx.doi.org/10...; https://urn.kb.se/re...; https://doi.org/10.2...; https://urn.kb.se/re...; https://lup.lub.lu.s...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

OBJECTIVE Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants.RESEARCH DESIGN AND METHODS We conducted a 14-cohort meta-analysis to assess the interaction of 20 genetic variants known to be related to glycemic traits and zinc metabolism with dietary zinc intake (food sources) and a 5-cohort meta-analysis to assess the interaction with total zinc intake (food sources and supplements) on fasting glucose levels among individuals of European ancestry without diabetes.RESULTS We observed a significant association of total zinc intake with lower fasting glucose levels (β-coefficient ± SE per 1 mg/day of zinc intake: -0.0012 ± 0.0003 mmol/L, summary P value = 0.0003), while the association of dietary zinc intake was not significant. We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: -0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it. None of the other interaction tests were statistically significant.CONCLUSIONS Our results suggest that higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Our findings also support evidence for the association of higher total zinc intake with lower fasting glucose levels.

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By the author/editor: Kanoni, Stavroul ...; Nettleton, Jenni ...; Hivert, Marie-Fr ...; Ye, Zheng; van Rooij, Frank ...; Shungin, Dmitry; show more...; Sonestedt, Emily; Ngwa, Julius S; Wojczynski, Mary ...; Lemaitre, Rozenn ...; Gustafsson, Stef ...; Anderson, Jennif ...; Tanaka, Toshiko; Hindy, George; Saylor, Georgia; Renström, Frida; Bennett, Amanda ...; van Duijn, Corne ...; Florez, Jose C; Fox, Caroline S; Hofman, Albert; Hoogeveen, Ron C; Houston, Denise ...; Hu, Frank B; Franks, Paul; Johansson, Ingeg ...; Lind, Lars; Liu, Yongmei; McKeown, Nicola; Ordovas, Jose; Pankow, James S; Sijbrands, Eric ...; Syvänen, Ann-Chr ...; Uitterlinden, An ...; Yannakoulia, Mar ...; Zillikens, M Car ...; Wareham, Nick J; Prokopenko, Inga; Bandinelli, Stef ...; Forouhi, Nita G; Cupples, L Adrie ...; Loos, Ruth J; Hallmans, Göran; Dupuis, Josée; Langenberg, Clau ...; Ferrucci, Luigi; Kritchevsky, Ste ...; McCarthy, Mark I; Ingelsson, Erik; Borecki, Ingrid ...; Witteman, Jacque ...; Orho-Melander, M ...; Siscovick, David ...; Meigs, James B; Franks, Paul W; Dedoussis, Georg ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Diabetes

By the university: Umeå University; Uppsala University; Lund University; Karolinska Institutet

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Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant : a 14-cohort meta-analysis

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